By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach
New twentieth Edition! This bestselling and common source on pediatric antimicrobial remedy offers quick entry to trustworthy, up to the moment strategies for therapy of all infectious ailments in young ones.
For each one disorder, the authors supply a statement to aid overall healthiness care services pick out the easiest of all antimicrobial choices. Drug descriptions conceal all antimicrobial brokers to be had at the present time and comprise whole information regarding dosing regimens. in accordance with transforming into issues approximately overuse of antibiotics, this system comprises guidance on while to not prescribe antimicrobials.
Practical, evidence-based ideas from the specialists in antimicrobial treatment:
Developed by way of individual editorial board
Designed when you look after childrens and are confronted with judgements each day
Includes remedy of parasitic infections and tropical medicine.
Updated exams concerning the power of the advice and the point of facts for therapy ideas for significant infections
Anti-infective drug directory, entire with formulations and dosages
Antibiotic treatment for overweight children
Antimicrobial prophylaxis/prevention of symptomatic infection
Maximal grownup dosages and better dosages of a few antimicrobials standard in children
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Additional resources for 2014 Nelson's Pediatric Antimicrobial Therapy
Newborns Cefixime 8 mg/kg/day PO as a single daily dose has not yet been studied in children but is recommended as step-down therapy in adults, to complete a 7-day treatment course. 40 For MSSA: cephalexin OR cloxacillin caps for older children. For Kingella, most penicillins or cephalosporins (but not clindamycin). 41 Arthritis, bacterial36–40 NOTE: CA-MRSA (see Chapter 4 on CA-MRSA) is increasingly prevalent in most areas of the world. Recommendations below are given for CA-MRSA and MSSA. Antibiotic recommendations for empiric therapy should include CA-MRSA when it is suspected or documented, while treatment for MSSA with beta-lactam antibiotics (like cephalexin) is preferred over clindamycin.
For penicillin allergy, ciprofloxacin (for Pasteurella) plus clindamycin (BIII). indb 40 Penicillin G 200,000 U/kg/day IV div q6h (BII) initially then penicillin V 100 mg/kg/day PO div qid OR amoxicillin 50 mg/kg/day PO div tid for 10 days Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (CII) CA-MRSA: clindamycin 40 mg/kg/day IV div q8h OR vancomycin 40 mg/kg/day IV q8h (CIII) Lymphangitis, blistering dactylitis (group A streptococcus)1,2,7 Myositis, suppurative26 (S aureus, including CA-MRSA; synonyms: tropical myositis, pyomyositis) Aggressive, emergent debridement; consider IVIG to bind bacterial toxins for life-threatening disease; use clindamycin to help decrease toxin production; abscesses may develop with CA-MRSA while on therapy.
Given the complexities of maturing organ function and drug elimination during the first few months of life, together with the wide variation in “compartments” for drug diffusion from very premature infants to term infants over the first months of life, these dosing recommendations represent our best estimates, but each infant should be independently evaluated for the appropriate dose. See also Table A for information on anti-influenza and antiretroviral drug dosages. Antibiotic B. indb 32 PO Erythromycin IV, PO IV, PO – treatment (start with initial loading dose)j – prophylaxis Fluconazole IV 25 q24h IV, IM Chloramphenicoli Daptomycin 100 div q12h IV, IM Cefuroxime IV, IM, PO - IV, IM Ceftriaxoneh Clindamycin 100 div q12h IV, IM Ceftazidime 6 mg/kg/dose twice wkly 12 q24hj 20 div q12h 12 div q12h 10 div q12h 70 div q12h IV, IM Ceftoxitin 100 div q12h 100 div q12h IV, IM IV, IM 50 div q12h IV, IM Cefotaxime Cefepime g 25/m2 q24h IV Caspofunginf Cefazolin 0–7 days old Route 6 mg/kg/dose twice wkly 12 q24hj 30 div q8h 12 div q12h 15 div q8h 50 div q12h 150 div q8h - 150 div q8h 100 div q8h 150 div q8h 150 div q8h 50 div q12h 25/m2 q24h 8–28 days old a 6 mg/kg/dose twice wkly 12 q24hj 20 div q12h 12 div q12h 15 div q8h 25 q24h 100 div q12h 50 q24h 100 div q12h 100 div q8h 100 div q12h 150 div q8h 50 div q12h 25/m2 q24h 6 mg/kg/dose twice wkly 12 q24hj 30 div q8h 12 div q12h 20 div q6h 50 div q12h 150 div q8h 50 q24h 150 div q8h 100 div q8h 150 div q8h 150 div q8h 75 div q8h 25/m2 q24h 8–28 days old Body Weight >2,000 g 0–7 days old Chronologic Age ≤28 days Body Weight ≤2,000 g Antibiotic 5 Dosages (mg/kg/day) and Intervals of Administration Antimicrobial Therapy for Newborns B.