By Donald J. Hanahan
This booklet offers a concise creation to phospholipid chemistry and is meant for a huge viewers of biologists, biochemists, and graduate scholars. constructed as a part of a graduate direction on lipids, this ebook additionally serves as a reference for laboratory investigators on sign transduction and organic membranes. the 1st a part of the textual content is dedicated to an orientation to the chemical nature of lipids as a rule, how they're regarded as linked within the phone, and the method during which the mobile lipids (including the phospholipids) may be recovered from cells and subjected to an preliminary id. next chapters represent the choline-containing phospholipids, together with the sphingolipids, the non-choline containing phospholipids, and eventually, the so-called minor phospholipids. The latter compounds, which act as agonists or lipid chemical mediators on cells, shape a forefront of a brand new class of biologically lively components and feature set the research of mobile phospholipids on a brand new and exiting path. most significantly, this e-book presents a foundation for extra inquiry on those advanced molecules, exhibiting that even though the compounds are precise, with care and knowing, they are often studied very easily
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Extra info for A Guide to Phospholipid Chemistry
FIGURE 2-1. An illustration of the interaction via polarization forces between membrane phospholipid and peptide. ASSOCIATIONS IN CELLULAR STRUCTURES 29 As an example, the charged phosphate group on phosphatidylethanolamine, for example, can interact with the hydrocarbon (CH2) chain of an amino acid—for example, valine—in a peptide. A similar situation would hold in the example to the right for interaction of the hydrocarbon unit in a peptide chain. In both instances the groups with permanent dipole moments can induce a temporary dipole moment in an adjacent molecule.
If the sample has been stored at low temperature, be sure to allow it to warm to room temperature and to mix it well since solvent and sample layering can occur. , glucose), free amino acids, nucleotides and so on—can be accomplished by the procedure of Wells and Dittmer (1963). 5, v/v), is passed through a previously washed column of Sephadex G-25, the effluent is collected and saved, and the column is then washed with a mixture of chloroform-methanol (2:1, v/v). The second eluent is collected and combined with the first and will contain all the phospholipid, free of contaminants.
These "induction" forces, though of low energy, are of some import in the binding of lipids and proteins. FIGURE 2-1. An illustration of the interaction via polarization forces between membrane phospholipid and peptide. ASSOCIATIONS IN CELLULAR STRUCTURES 29 As an example, the charged phosphate group on phosphatidylethanolamine, for example, can interact with the hydrocarbon (CH2) chain of an amino acid—for example, valine—in a peptide. A similar situation would hold in the example to the right for interaction of the hydrocarbon unit in a peptide chain.